A big point of confusion in dealing with canine epilepsy is figuring out the difference between rescue medications (like intranasal Midazolam or rectal diazepam) and cluster buster medications (like Levetiracetam (aka Keppra) or Clorazepate). I see so much misinformation out there, so let’s break it down simply:
- Rescue Meds are designed to stop a seizure that’s happening right now. Think of them like the emergency brake. Midazolam (given intranasally) or diazepam (rectally) are two of the most common. You keep them on hand for when your dog is actively seizing and needs help breaking free from it. The longer a dog seizes the higher their risk for developing serious complications.
- Cluster Buster Meds are used when your dog has already had a seizure, and you want to prevent more from following. For example, if your dog has a seizure at 10 a.m. and you know they tend to cluster, your vet may recommend giving extra Keppra or clorazepate to help break that cycle.
Knowing the difference is so important—rescue meds stop the seizure in the moment, cluster busters are about preventing a whole wave from rolling in after.
I created a free printable for you—something you can save to your phone or print out and keep on the fridge. It’s a quick reference for when to reach for a rescue med vs. when to grab a cluster buster. You’ll find it at the end of this blog post.
💜 Forrest Update:
My sweet boy Forrest just had another seizure, and this time he only went 14 days between them. We’re really praying this isn’t his new pattern of seizing every two weeks. It feels discouraging right now and I’m not sleeping well because the last one caught me off guard and now I don’t know when to expect his next one—not that I ever did, but it’s easy to start to feel that way when their pattern has been one way for a bit then it shifts. Part of the never ending roller coaster that is epilepsy. But I’m thankful to have tools and medications and the ability to do all that I can to keep him as safe as possible when a seizure does happen.
If your pup is also navigating seizures, you’re not alone! Please feel free to share this blog with others—so many dogs are experiencing seizures, and their people need support and encouragement too. ❤️🩹
✨ A note of encouragement:
Every dog is different. What works for one may not work for another, which is why it’s so important to advocate for your dog, ask your vet questions, and do your own research. ChatGPT has been such an amazing tool for us—it helps me research meds, gather info, prepare questions for our vet and neurologist, and learn new ways to support Forrest.
From our lavender world of grace — we’re holding onto hope and walking by faith. 💜
The Epi Dog Mom Blog 
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